North America Oligonucleotide Synthesis Market Size, Share, Comprehensive Analysis, Opportunity Assessment by 2027

The North America Oligonucleotide Synthesis market is expected to reach US$ $ 1,541.03 Mn in 2027 from US$ 609.90 Mn in 2018. The market is estimated to grow with a CAGR of 11.2% from 2019-2027.

The List of Companies

  1. Thermo Fisher Scientific Inc.
  2. GenScript
  3. Molecular Assemblies
  4. Twist Biosciences
  5. Evonetix
  6. DNA Script
  7. Nuclera Nucleics
  8. Camena Bioscience
  9. Synthomics
  10. Ansa Biotechnologies

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The growth of the oligonucleotide synthesis market is driven by several key factors, including rising investments in pharmaceutical and biotechnology companies, increased funding from government bodies, and the growing number of market players focusing on this sector. These factors are expected to accelerate market expansion in the region during the forecast period.

Oligonucleotides play a crucial role in various biological applications, acting as sequence-specific binding agents to help identify specific target DNA sequences. Synthetic oligonucleotides, which are short single-stranded DNA sequences, have diverse applications in disease diagnosis, biotechnology research, therapeutics, forensics, and drug discovery. In particular, they are widely used in the diagnosis of genetic diseases. For example, oligonucleotide probes can detect single base pair mutations in the human genome. A notable instance is sickle cell anemia, which results from a transversion (A→T) within the β-globin gene. Labeled oligonucleotides, under stringent hybridization conditions, enable the detection of whether an individual carries one or both mutant alleles.

Additionally, researchers are leveraging oligonucleotides for more efficient and environmentally friendly chemical synthesis. By assembling oligonucleotides into longer DNA fragments encoding synthetic genes, bacteria or yeast cells can be programmed to produce specific enzymes, which serve various industrial and medical purposes.

Oligonucleotides also play a significant role in therapeutic advancements by enabling the targeting, modulation, and silencing of malfunctioning genes. A prime example is Ionis Pharmaceuticals, which specializes in developing antisense oligonucleotide (ASO) therapeutics. The growing potential of synthesized oligonucleotides across multiple fields is a key driver of market growth.

Recent clinical trials in Canada have further supported the expansion of the oligonucleotide synthesis market. For instance, in January 2019, a Phase 3 clinical trial was launched to assess the investigational therapy RG6042 for treating Huntington’s disease in both the United States and Canada. Originally known as IONIS-HTTRx, RG6042 is an antisense oligonucleotide treatment initially developed by Ionis Pharmaceuticals and later acquired by Roche. It is specifically designed to target and eliminate various forms of mutant huntingtin protein (mHTT), the primary cause of Huntington’s disease. The trial is being conducted across six sites in five Canadian provinces.

The United States is expected to dominate the North American oligonucleotide synthesis market due to substantial investments and increasing funding allocated to manufacturing companies, academic institutions, and research centers. This funding supports the development of gene synthesis-based end products, including precision medicine and advanced therapeutics. As a result, the U.S. is projected to contribute the largest market share in the region throughout the forecast period.

Other Reports:

Europe Polyacrylamide Market: https://business-market-insights1.blogspot.com/2025/03/europe-polyacrylamide-market-analytical.html 

Europe Probiotic Supplements Market: https://business-market-insights1.blogspot.com/2025/03/europe-probiotic-supplements-market.html 

Europe Surgical Robots Market: https://business-market-insights1.blogspot.com/2025/03/europe-surgical-robots-market-share.html 

About Us:

Business Market Insights is a market research platform that provides subscription service for industry and company reports. Our research team has extensive professional expertise in domains such as Electronics & Semiconductor; Aerospace & Defense; Automotive & Transportation; Energy & Power; Healthcare; Manufacturing & Construction; Food & Beverages; Chemicals & Materials; and Technology, Media, & Telecommunications

Author’s Bio:

Suryakant Gadekar

Senior Market Research Expert at Business Market Insights


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